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KMID : 1177320100130010050
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Korean Journal of Schizophrenia Research
2010 Volume.13 No. 1 p.50 ~ p.57
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Neural Mechanism of Emotional Perception According to the Goal of Attribution in Patients with Schizophrenia
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Choi Won-Jung
Park Kyung-Min
Lee Hyeong-Rae
Ku Jeong-Hun
Kim Sun-Il
Kim Jae-Jin
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Abstract
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Objective：Emotional perception involves not simply identification but also attribution of the expressions. A number of functional neuroimaging studies have investigated the identification of emotional expressions, but emotional perception according to the goal of attribution remains unclear in patients with schizophrenia.
Method：Fifteen patients with schizophrenia and 16 healthy controls underwent functional MRI while performing 6 different attribution tasks (happy-certain, happy-uncertain, angry-certain, angry-uncertain, neutral-certain, and neutral-uncertain). Relationships between signal changes of the dysfunctional regions and clinical symptoms in the patients were examined.
Results：In the happy condition, the patient group showed smaller signal changes in the frontal eye field (FEF), and the FEF signal changes were related to negative symptoms. In the angry condition, the patient group exhibited larger signal changes of the temporal pole (TP), but smaller ones of the fusiform gyrus and middle temporal gyrus. The TP signal changes had a tendency level of association with positive symptoms.
Conclusion：Patients with schizophrenia could have different impairments in emotional perception in the context of the
goal of attribution according to valence, which could be based on separable neural mechanisms and linked to different clinical symptoms.
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KEYWORD
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Schizophrenia, Emotional perception, Attribution, Frontal eye field, Temporal pole
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